Recent Developments on Brønsted Acid Catalyzed Asymmetric Aldol Reactions and the Fate of the Catalysts

Since the innovative work of Terada and Akiyama, asymmetric reaction using chiral Brønsted acid has attracted great attention. Asymmetric aldol reactions are extensively studied in different organocatalysis. acid-catalyzed may be carried out directly without modification substrates or Mukaiyama type silyl enol ether as nucleophiles. The proceed through formation intermediate followed by attack to electrophile while follow two mechanistic pathways- acidic pathways where activates substrate Lewis acts pre-catalyst. Here, recent advancement a catalyst fate catalysts been discussed this review. It is observed that some kinds have rarely need more